Dr. Comings Publications #401+
401. Comings, D. E., Gade-Andavolu, R., Blake, H., Muhleman, D., M. Huss, G. Saucier, and J. P. MacMurray. Role of genetic variants at the
neutral endopeptidase (MME) and aminopeptidase N (ANPEP) genes for enkephalin degradation in depression and anxiety.
Molecular Psychiatry 4: S104, 1999.
402. Comings, D. E., Gade-Andavolu, R., Gonzalez, N., Blake, H., S. Wu, and J. P. MacMurray. Additive effect of three noradrenergic genes
(ADRA2A, ADRA2C, DBH) on attention deficit hyperactivity disorder and learning disabilities in Tourette syndrome subjects.
Clin.Genet. 55: 160-172, 1999.
403. Comings, D. E., Gonzalez, N., S. Wu, Gade, R., Muhleman, D., G. Saucier, P. Johnson, R. Verde, R. J. Rosenthal, H. R. Lesieur, L. J.
Rugle, W. R. Miller, and J. P. MacMurray. Studies of the 48 bp repeat of the DRD4 gene in impulsive-addictive behaviors:
Tourette syndrome, ADHD, pathological gambling, and substance abuse. Am.J.Med.Gen.(Neuropsych.Genet.) 88: 358-368, 1999.
404. Comings, D. E., Gonzalez, N., S. Wu, G. Saucier, P. Johnson, R. Verde, and J. P. MacMurray. Association of the dopamine
DRD3 receptor gene with cocaine dependence. Molecular Psychiatry 4: 484-487, 1999.
405. Comings, D. E., J. P. MacMurray, Gonzalez, N., L. Ferry, and W. R. Peters. Association of the serotonin transporter gene with serum
cholesterol levels and heart disease. Molecular Genetics and Metabolism 67: 248-253, 1999.
406. Comings, D. E., Muhleman, D., P. Johnson, and J. P. MacMurray. Potential role of the estrogen receptor gene (ESR1) in anxiety.
Molecular Psychaitry 4: 374-377, 1999.
407. Gade-Andavolu, R., MacMurray, J., W. Peters, and Comings, D.E.,. Association of PST-1 polymorphism in insulin gene (INS3) with
obesity and novelty seeking. Moleuclar Psychiatry 4: 106, 1999.
408. Peters, W. R., K. Khollefi, MacMurray, J., Muhleman, D., and Comings, D.E.,. Possible relevance of neuropeptide Y and aromatase
polymorphisms to leptin metabolism and obesity-related features. Molecular Psychiatry 4: S111, 1999.
409. Miles, T., Comings.D.E., Gonzalez, N., N. Tuan, E. Sellers, R. Tyndale, S. George, and B. O’Dowd. Allele and haplotype frequencies of
the serotonin transporter (SCL 6A4) in Tourettes syndrome and alcohol dependence. Molecular Psychiatry 4: S95, 1999.
410. Miller, W. B., D. J. Pasta, MacMurray, J., C. Chiu, H. Wu, and Comings, D.E.,. Dopamine receptor genes are associated with age at first
intercourse. J. Biosocial Science 31: 43-54, 1999.
411. Huss, M., MacMurray, J., Dietz, G., Blake, H., U. Lehmkuhl, and Comings, D.E.,. Opioids and attachment behavior: Studies of the neutral
endopeptidase gene. Molecular Psychiatry 4: S45, 1999.
412. Winsberg, B. and Comings, D. Association of the dopamine transporter gene (DAT1) with poor methylphenidate response.
J.Am.Acad.Child.Adolesc.Psychiatry 38: 1474-1477, 1999.
413. Wu, S. and Comings, D.E. Two single nucleotide polymorphisms in the promoter region of the human phenylethanolamine
N-methyltransferase PNMT gene. Psychiatric Genetics 9:187-188, 1999.
414. Winsberg, B. and Comings, D.E.,. Association of homozygosity for the dopamine transporter with poor methylphendidate response.
Molecular Psychiatry 4: S87, 1999.
415. Wu, S. and Comings, D.E.,. A common C-1018G polymorphism in the human 5-HTR1A receptor gene. Psychiat.Genet. 9: 105-106, 1999.
416. Comings, D. E. Molecular genetics of violence. In: Encyclopedia of Violence in the United States. Edited by R. Rottesman, New York,
Charles Schribner's Sons, Vol. 2, pp24-25,1999
417. Comings, D. E. Molecular genetics of ADHD and conduct disorder: Relevance to the treatment of recidivistic antisocial behavior.
In Fishbein, D., ed. Science, Treatment and Prevention of Antisocial Behavior: Application to the Criminal Justice System.
New York, N.Y., Civic Research Institute, Inc. 16.1-25, 2000.
418. Comings,D.E., MacMurray,J.P. MiniReview Molecular Heterosis: A Review Molecular Genetics and Metabolism 71:19-31,2000
419. MacMurray, J. and Comings, D.E.,. A study of factors involved in mediation of age at childbearing and offspring sex-ratio.
In Rogers, J. and D. Rowe,Eds. Genetics of Fertility, 2000.
420. MacMurray, Kovacs,B., McGue, M., Johnson,J.P., Blake, H., Comings, D.E. Association between the endothelialion nitric oxide synthase
gene (NOS3) reproductive behaviors, and twinning, Genetic Influence on Fertility and Sexuality.
Kluwer Academic Publishers. 303-316,2000
421. Blum, K., E. R. Braverman, J. G. Cull, J. M. Holder, J. Lubar, and Comings, D.E.,. Reward deficiency syndrome (RDS): A biogenic model
for the diagnosis and treatment of impulsive, addictive and compulsive behaviors. J.Psychoactive Drugs. 32 Supplement 1-112, 2000.
422. Comings, D. E. Age of first childbirth: A major selective factor for psychiatric genes in the twentieth century. In: Genetic Influences on
Fertility and Sexuality, Edited by J. Rogers, and D. Rowe, 271-288, 2000.
423. Comings, D. E., Gade-Andavolu, R., Gonzalez, N., S. Wu, Muhleman, D., Blake, H., Dietz, G., G. Saucier, and J. P. MacMurray.
Comparison of the role of dopamine, serotonin, and noradrenergic genes in ADHD, ODD and conduct disorder. Multivariate
regression analysis of 20 genes. Clinical Genetics 57:178-196, 2000.
424. Comings, D. E., Muhleman, D., S. Wu, and J. P. MacMurray. Association of the N-α-acetyltransferase gene (NAT1) with mild and severe
substance abuse. NeuroReport, 11:1227-1230, 2000.
425. Comings, D. E. ADHD with Tourette Syndrome or Tic Disorders. In Brown, T. E., ed. Attention Deficit Disorders and Comorbidities in
Children, Adolescents and Adults. Washington, Am.Psychiat.Press. 2000.
426. Comings, D. E., Dietz, G., Gade-Andavolu, R., Blake, H., Muhleman, D., M. Huss, G. Saucier, and J. P. MacMurray. Association of the
neutral endopepdidase (MME) gene with depression and anxiety. Psychiatric Genetics 10:91-94, 2000.
427. Comings, D. E., J. P. Johnson, N. S. Gonzalez, M. Huss, G. Saucier, and MacMurray, J. Association between the adrenergic a 2A receptor
gene (ADRA2A) and measures of irritability, hostility, impulsivity and memory in normal subjects.
Psychiatric Genetics 10:160-172,2000.
428 Comings, D. E. and MacMurray, J.P. Molecular Heterosis: A Review. Molecular Biology & Metabolism 71: 19-31, 2000.
429 Comings, D.E., Gade-Andavolu, R., Gonzalez, N., S. Wu, Muhleman, D., Blake, H., Chiu, F., Wang,E., Farwell, K., Darakjy, S., Baker,
R., Dietz, G., G. Saucier, and J. P. MacMurray. Multivariate analysis of associations of 42 genes in ADHD, ODD and
conduct disorder. Clinical Genetics 58:31-40, 2000.
430 Huss,M.,MacMurray,J., Johnson,P., Lehmkuhl,U., Comings,D.E. The impact of father-absence on age at menarche and sexual symptoms in
children and aldosescents admitted for educational and behavioral problems. In Peter,H-P. and Rogers,J.L. eds
The Biodemography of Fertility. Kluwer Academic Publishers Aug 14-15, 2000.
431 Comings,D.E., Johnson,J.P., Gonzalez,N.S., Huss,M., Saucier,G., McGue,M., MacMurray,J.P. Association between the adrenergic receptor
gene (ADRA2A) and measures of irritability, hostility, impulsivity and memory in normal subjects. Psychiatric Genetics 10:39-42,2000
432 Comings.,D.E, Gade-Andavolu,R., Gonzalez,N., Wu,S., Muhleman,D., Blake,H., Mann,M.B., Dietz,G., Saucier,G., MacMurray,J.P. A
multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory.
Clinical Genetics 58:375-385,2000
433 Comings, D,E, and Blum, K. Reward deficiency syndrome: genetic aspects of behavioral disorders. Progress in Brain Research.
126: 325-341, 2000.
434 Asherson, P. Barkley, R. Barr, C. Berg, K. Biederman, J. Castellanos, X. Comings, D. Curran, S. Doyle, A. Ebstein, R. Eisenberg, J. Ergelen, E.
Faraone, S. Freund, L. Geller, D. Gill, M. Holmes, J. Hudziak, J. Kennedy, J. Kent, L. Manor, I. Mick, E. Mitchell, H. Navia, B. Pato, C.
Pato, M. Price, T. Sargeant, J. Simonoff, E. Smalley, S. Spencer, T. Swanson, J. Waldman, I. Wilens, T. Yazgan, Y.. Collaborative
possibilities for molecular genetic studies of attention deficit hyperactivity disorder: Report from an international conference.
Am. J. Medical Genetics 96:251-257, 2000.
435 Comings,D.E., Gonzalez,N., Saucier,G.,Johnson, J.P., McMurray,J. The DRD4 gene and the spiritual transcendence scale of the character
temperament index. Psychiatric Genetics 10:185-189,2001
436 Madrid, G.A., MacMurray, J., Lee, J.W. Anderson, B.A., Comings, D.E., Stress as a Mediating Factor in the association between the
DRD2 Taq I Polymorphism and Alcoholism. Alcohol 23:117-122, 2001.
437 Comings,D.E.,Gade,R.,Muhleman,D.,Peters,W.R.,MacMurray,J. The LEP Gene and Age of Menarche: Maternal Age as a Potential Cause of
Hidden Stratification in Association Studies. Molecular Genetics and Metabolism 73: 204-210, 2001
438 Comings,D.E.., Gade-Andavolu, R.,Gonzalez, N., S. Wu, Muhleman, D., Chen, C.,Koh, P., Farwell, K., Blake, H., Dietz, G., MacMurray, J. P.,
Lesieur, H.R., Rugle, L.J., Rosenthal, R.J. The Additive effect of Neurotransmitter Genes in Pathological Gambling.
Clinical Genetics 59:00-00, 2001
439 Mann,M., Wu,S., Rostamkhani,M.,Tourtellote,W.,MacMurray,J.,ComingsD.E. Phenylethanolamine N-Methyltransferase (PNMT) Gene and
Early-Onset Alzheimer Disease. American Journal of Medical Genetics (Neuropsychiatric Genetics) 105:312-316,2001
440 Comings,D.E., Wu,S., Gonzalez,N., Iacono,W.G., McGue,M., Peters,WW., MacMurray,J. Cholecystokinin (CCK) Gene as a Possible Risk
Factor for Smoking: A Replication in Two Independent Samples. Molecular Genetics and Metabolism 73:347-353,2001
441 Comings, D.E., Clinical and Molecular Genetics of ADHD and Tourette Syndrome. Adult Attention Deficit Disorder Brain Mechanisms and
Life Outcome, Annals of the New York Academy of Sciences 931:50-83, 2001
442 Comings.,D.E., Gade-Andavolu,R., Gonzalez,N., Wu,S., Muhleman,D., Chen,C., Koh,P., Farwell,K., Blake,H., Dietz,G., MacMurray,J.P.,
Lesieur,H.R., Rugle,L.J., Rosenthal,R.J. The additive effect of neurotransmitter genes in pathological gambling.
Clinical Genetics 60:107-116, 2001
443 Comings, D.E. and MacMurray, J.: Maternal age as a confounding variable in association studies. Am.J. Medical Genetics Neuropsychiatric
Genetics 105:565, 2001.
444 Comings, D.E., Sujihan Wu, M. Rostamkhani, McGue, M., Iacono, W., MacMurray,J. Association of the Muscarinic Cholinergic 2 Receptor
(CHRM2) Gene With Major Depression in Women. Nueorpsychiatric Genetics 114:527-529, 2002
445 Comings, D. E., G. Saucier, and J. P. MacMurray. The role of the DRD2 and other dopamine genes in personality traits. In Benjamin, J., R. P.
Ebstein, and R. H. Belmaker, eds. Molecular Genetics and Human Personality. American Psychiatric Press. 165-191, 2002.
446 Comings,D.E., Muhleman,D., Johnson,J.P., MacMurray,J.P. Parent-Daughter transmission of the Androgen Receptor (AR) gene as an
explanation of the effect of father absence on age of menarche. Child Development. 73:1046-1051, 2002.
447 Bottini,N., MacMurray,J., Peters,W, Rhostamkhani,M., Comings,D.E. Association of the acid phosphatase (ACP1) gene with triglyceride levels in
obese women. Molecular Genetics and Metabolism. 77:226-229, 2002.
448 Bottini, N., MacMurray,J., Rostamkani, M., McGue, M., Iacono, W. G., Comings,D.E. Association between the low molecular weight cytosolic
acid phosphatase gene ACP1*A and comorbid features of Tourette syndrome. Neuroscience Letters 330:198-200, 2002.
449 Comings, D.E. New technique for the genetic study of behavioral disorders. J. Child. Neurology 17:528, 2002.
450 MacMurray, J. and Comings, D.E. Associations between the DRD1 gene and anxiety disorders in Tourette syndrome patients: Interactions with
maternal age and parity. J.Child. Neurology 17:528-529, 2002.
451 MacMurray, J., Rhostamkani,M., Comings,D.E. Phenlyethanolaminen N-methyltransferase gene and Tourette syndrome.
J. Child Neurology 17: 529, 2002.
452 MacMurray, J. and Comings, D.E Association between the DRD2 Taq I polymorphism and obsessive-compulsive disorder in patients with
Tourette syndrome: Integration with maternal age and parity.. J. Child Neurology 17: 529-530, 2002.
453 Comings, D.E.: Epistasis in Autism. J. Child Neurology 17:531-532, 2002.
454 MacMurray,J, Madrid,A., Bottini,E.//Muhleman,D.,Comings,D. Evidence of an emerging collision between the fertility transition and
genotype dependent fertility differentials. Rodgers,J.L. Kohler,H-P. eds. The Biodemography of Human Reproduction and Fertility
Kluwer Academic Publishers, Boston, 2002.
455 Comings,D.E., Wu,S., Rostamkhani,M., McGue,M.,Burt,A., MacMurray,J.P. Role of the cholinergic muscarinic 2 receptor (CHGRM2) gene in
cognition. Molecular Psychiatry 8: 91-13, 2003.
456 MacMurray, J.P., Comings, D.E. The Androgen Gee as an epistatic factor. Am J Med Genet (Neuropsychiatric Genetics) 112B: 52, 2003.
457. Comings, D. E. and MacMurray, J. P. Maternal age at the birth of the first child as an epistatic factor in psychiatric genetics.
Am J Med Genet (Neuropsychiatric Genetics) 122B: 52, 2003
458. Comings,D.E., Rostamkhani, M., Emami,R.. MacMurray, J.P.: Association between the vesicular monamine transporter VMAT and co-morbid
symptoms in Tourette’s syndrome patients. Am.J. Med. Genetics (Neurospychiatric Genetics) 122B: 51-52, 2003.
459 Comings, D.E Treatment of Tourette Syndrome. In. Rakel and Bope (eds) Coon's Current Therapy 2003. Elsiver Science (USA) New York,
983-987, 2003.
460 Comings, D.E.: The Real Problem with Association Studies Am. J. Med. Genet. (Neuropsychaitric Genetics). 116: 102, 2003.
461 Comings, D.E., Gade-Andavolu, R., Cone,L.A, Muhleman, D. MacMurray, J.P. A Multi-gene Test for the Risk of Sporadic Breast Cancer.
Cancer 97: 2160-2170, 2003.
462 Comings, D.E. Behavior Genetics – Human. In Encyclopedia of Life Sciences. Nature/MacMillian, London, 2003.
463 Comings, D.E.. Polygenic Inheritance. Nature Encyclopedia of the Genome. Nature MacMillian. 2003.
464 Comings,D.E., Gonzalez,N.S., Cheng,Li S-C., MacMurray,J. A "Line Item" approach to the identification of genes involved in
polygenic behavioral disorders: The adrenergic a2A (ADRA2A) gene. Am.J.Medical Genetics
(Neurospychiatric Genetics) 118B:110-114 2003.
465 Comings, D.E. 22% of preschool children, 8% of primary school students and 3% of adolescents have tics. Evidence Based Mental Health.
6:10, 2003.
466. Peters, W. R., MacMurry, J. P., Walker, J., Giese, R. J., Jr., Comings, D. E. Phenylethanolamine N-methyltransferase G-148A genetic variant
and weight loss in obese women. Obes. Res. 11:415-419, 2003
467 Bottini,N., Musumeci,L., Alonso,A., Rahmouni,S., Nika,K., Rostamkhani,M., MacMurray,J., Pellecchia,M., Eisenbarth,G.S., Comings,D.E.,
Mustelin,T. A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes. Nature Genetics 36:337-338, 2004.
468 Gade-Andavolu,R., Comings,D.E., MacMurray,J., Cheng, L. S-C.. Tourtellotte,W.W.. Rosthamkhani,M., Cone,L.A. Association of CCR5
delta32 deletion with early death in multiple sclerosis. Genetics in Medicine 6:126-131, 2004.
469 Gade-Andavolu, R.G., Comings, D.E., MacMurray,J., Vuthoori, R.K., Touretellott, W.W., Nagra, R.M., Cone, L.A.: RANTES:
A Genetic risk marker for multiple sclerosis, Multiple Sclerosis 10:535-539, 2004
470. Thompson, M.D., Comings, D., Abughazalah, R, Jeresch,Y., Wade, J., Sakurai,T., Tokita, S., Yoshida, T., Tanaka, H., Yanagisawa, M.,
Burnham,W.M., Moldfsky, H. : Variants of the Orexin2/hcrt2 receptor gene indentifies in patients with excessive daytime sleepiness and
patients with Tourette’s syndrome comorbidity. Amer. J. Med. Genetics Part B Neuropsychiatric genetics 129:69-75, 2004.
471 Comings, D.E., Chen, T.J., Blum, K. Blum, S.H.: Attention Deficit Hyperactivity Disorder: A common genetic disorder affecting how our brain
functions. Theoretical Biology & Medical Modelling 2:50, (December 23), 2005.
472 Chen TJ, Blum K, Mathews D, Fisher L, Schnautz N, Braverman ER, Schoolfield J, Downs BW, Comings DE.: Are dopaminergic genes
involved in a predisposition to pathological aggression? Hypothesizing the importance of "super normal controls" in psychiatricgenetic
research of complex behavioral disorders. Med. Hypothesis 65:703-707, 2005
473. Olin D, MacMurray J, Comings DE.: Risk of late-onset Alzheimer's disease associated with BDNF C270T polymorphism.
Neurosci Lett. 2005 Jun 24;381(3):275-8.
474. Comings, D.E. Thomas JH Chen, Kenneth Blum, Julie F Mengucci, Seth H Blum, Brian Meshkin. Neurogenetic interactions and aberrant
behavioral co-morbidity of attention deficit hyperactivity disorder (ADHD): dispelling myths. Theoretical Biology and Medical Modeling.
W:50 (23 December), 2005.
475. Blum, Ken, Ph.D. Thomas JK Chen, Ph.D. Seth H. Blum, B.A., David E Comings, M.D, Julie F. Foster R.N. Brian Meshkin, B.Sc, Bernard W.
Downs B.BA, Eric R. Braverman, M.D. Reward Deficiency Syndrome (RDS): Neurogenetic aspects of aging and related behavioral
disorders specific to dopaminergic pathways. In Klatz, R. and Goldman, R. Anti-Aging Therapetics. Volume VIII. American Academy of
Anti-Aging Medicine. A4M Publications. Chicago, Il. 9-26, 2006.
476. Comings, D.E. MacMurray, J.M. Maternal age at the birth of the first child as an epistatic factor in polygenic disorders.
Am.J. Med. Genetics B Neuropsychiatric Genetics. 141B 1-6, 2006
477. Comings, D.E. Genetics of Pathological Gambling and Substance Use Disorders. Meeting of the European Congress of
Neuropsychopharmacology. Paris, Sept 16-20, 2006, abstract in: European Neuropsychopharmacology 16 Supplement 4, 2006 pS181.
478. Blum, K, Thomas JH Chen, Brian Meshkin, Bernard W. Downs, Roger L Waite, Eric R. Braverman, Vanassa Arcuri, Alison Notaro, Julie F.
Mengucci, Seth H. Blum, Debasis Bagchi, Manashi Bagchi, Ariel Robarge, Gilbert Kaats, and David E. Comings. Pharmacogenomic &
Neutrigenomic Aspects of Neurobesigenics, A genetic Pleiotrophic Clinical Sybtype of Reward Deficiency Syndrome (RDS).
The Impact of Biomics Technology and DNA Directed Nutraceutical (GENOTRIM ™) Anti-Obesity Targeting of the Brain Reward
Circuitry Current Pharmacogenomics in press.
479. Thomas J.H. Chen Ph.D., Kenneth Blum Ph.D., Gilbert Kaats Ph.D., Eric Braverman M.D., Dennis Pullin Ph.D., Bernard W. Downs B.SC., M
Martinez-Pons., Seth H. Blum B.A., Julie Mengucci R.N., and Debasis Bagchi Ph.D., Manashi Bagchi Ph.D., Ariel Robarge M.Sc, Brian
Meshkin B.Sc. Vanessa Arcuri, B. Sc., Michael Varshavskiy, David E. Comings M.D. Correlation of the Taq1 Dopamine
D2 Receptor Gene and Percent Body Fat in Obese and Screened Control Subjects, Gene Therapy and Molecular Biology in Press, 2007.